BackgroundComponent of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
DescriptionAPOC3 Recombinant Monoclonal Antibody [8H12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP02656
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human APOC3
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesApolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3), APOC3
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200