BackgroundThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
DescriptionCLDN18 Recombinant Monoclonal Antibody [25E3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG1
Uniprot IDP56856
PurificationAffinity Chromatography
ImmunogenRecombinant Human CLDN18 protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesClaudin-18, CLDN18
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200