BackgroundTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
DescriptionCLDN6/9 Recombinant Monoclonal Antibody [9H8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG1
Uniprot IDP56747
PurificationAffinity Chromatography
ImmunogenRecombinant Human CLDN6/9 protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesClaudin-6 antibody; Claudin6 antibody; CLD6_HUMAN antibody; CLDN 6 antibody; CLDN6 antibody; OTTHUMP00000159248 antibody; Skullin 2 antibody; Skullin antibody; UNQ757/PRO1488 antibody
ApplicationELISA,FC