BackgroundResponsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
DescriptionDio3 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityRat
IsotypeIgG
Uniprot IDP49897
PurificationProtein G purified
ImmunogenRecombinant Rat Thyroxine 5-deiodinase protein (37-278AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative Names5DIII, DIOIII, Type 3 DI, Type-III 5'-deiodinase, Dio3, Itdi3, Txdi3
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000