BackgroundInteracts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
DescriptionDLG4 Recombinant Monoclonal Antibody [1H4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse, Rat
IsotypeRabbit IgG
Uniprot IDP78352
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human PSD95
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesDisks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90), DLG4, PSD95
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000