BackgroundInitiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
DescriptionEDEM2 Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ9BV94
Purification>95%, Protein G purified
ImmunogenRecombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesER degradation-enhancing alpha-mannosidase-like protein 2, EDEM2, C20orf31, C20orf49, UNQ573/PRO1135
ApplicationELISA; Recommended dilution: ELISA 1:100-1:500