BackgroundFibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation.
DescriptionFN1 Recombinant Monoclonal Antibody [25A1]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP02751
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from Human FN1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesFibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin, Ugl-Y1, Ugl-Y2, Ugl-Y3], FN1, FN
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200