BackgroundThe large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
DescriptionGM2A Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP17900
PurificationProtein G purified
ImmunogenRecombinant Human Ganglioside GM2 activator protein (32-193AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesCerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, GM2A
ApplicationELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-5000, IHC:1:20-1:200, IP:1:200-1:2000