BackgroundThe H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
DescriptionHRH3 Recombinant Monoclonal Antibody [27H8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ9Y5N1
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human HRH3
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesHistamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97), HRH3, GPCR97
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200