BackgroundIn cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation.
DescriptionHspa1b Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityMouse
IsotypeIgG
Uniprot IDP17879
Purification>95%, Protein G purified
ImmunogenRecombinant Mouse Heat shock 70 kDa protein 1B protein (2-642AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesHeat shock 70 kDa protein 1B, Hspa1b, Hcp70.1, Hsp70-1, Hsp70a1, Hspa1, Heat shock 70 kDa protein 1, HSP70.1
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000