BackgroundThis is a G-protein coupled receptor for serotonin, known as 5-hydroxytryptamine. It also acts as a receptor for drugs like ergot alkaloid derivatives, DOI, and LSD. When ligands bind, the receptor's conformation changes, initiating signaling through G proteins, which then affects downstream effectors. Beta-arrestin family members inhibit G protein signaling and activate alternative pathways. This leads to a phosphatidylinositol-calcium second messenger system activation, influencing phosphatidylinositol 3-kinase and downstream cascades, and promoting intracellular Ca(2+) release. The receptor regulates brain activity via transient receptor potential calcium channels, impacting pro-opiomelanocortin neurons and CRH release, subsequently affecting corticosterone release. It plays roles in appetite regulation, response to stress and anxiety-inducing stimuli, as well as insulin sensitivity and glucose homeostasis.
DescriptionHTR2C Recombinant Monoclonal Antibody [9H8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP28335
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human 5HT2C Receptor
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative Names5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C), HTR2C, HTR1C
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200