BackgroundThe enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
DescriptionKLKB1 Recombinant Monoclonal Antibody [9F6]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP03952
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human KLKB1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesPlasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain, Plasma kallikrein light chain], KLKB1, KLK3
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200