BackgroundLysophosphatidic acid (LPA) receptor influencing actin cytoskeleton, cell migration, differentiation, proliferation, and responses to damage. Activates G-proteins, triggers Ca(2+) increase, MAP kinase activation, and Rho signaling. Shapes cells, drives neurite retraction and stress fiber formation. Involved in chemotaxis, inflammation, cell proliferation, and brain/neuron development. Crucial for skeleton and dentate gyrus neuron processes. Implicated in pain perception and neuropathic pain initiation.
DescriptionLPAR1 Recombinant Monoclonal Antibody [4C3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ92633
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human EDG2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesLysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2), LPAR1, EDG2 LPA1
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000