BackgroundThe protein produced by this gene, known as low density lipoprotein-related protein 2 (LRP2) or megalin, functions as a versatile endocytic receptor expressed in various tissues, notably absorptive epithelial tissues like the kidney. This glycoprotein features a large amino-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail at its carboxy-terminal end. The extracellular ligand-binding domains facilitate the binding of diverse macromolecules, including albumin, apolipoproteins B and E, and lipoprotein lipase. LRP2 is crucial for the uptake of numerous ligands, such as lipoproteins, sterols, vitamin-binding proteins, and hormones. Additionally, it contributes to cell signaling; its extracellular ligands encompass parathyroid hormones and the morphogen sonic hedgehog, while its cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. The recycling of this membrane receptor is regulated through phosphorylation of its cytoplasmic domain. Mutations in this gene are associated with Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
DescriptionLRP2 Recombinant Monoclonal Antibody [10B5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP98164
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human LRP2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesLow-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin), LRP2
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200