BackgroundTranscriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
DescriptionLRRFIP1 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ32MZ4
Purification>95%, Protein G purified
ImmunogenRecombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesLRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein, GCF2, TRIP, LRRFIP1
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000