BackgroundThe protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the pre-replicative complex. The encoded protein stabilizes the ORC and, therefore, aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene.
DescriptionLrwd1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.01% thimerosal,50% glycerol, pH 7.3.
SpecificityHuman
IsotypeIgG
Uniprot IDQ9UFC0
PurificationAffinity Purified
ImmunogenStoragA synthetic peptide corresponding to a sequence within amino acids 250-350 of human Lrwd1 (NP_690852.1).e
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycles.
Alternative NamesLRWD1; CENP-33; ORCA; Lrwd1
ApplicationWB, ELISA; Recommended dilution: WB 1:500 - 1:2000