BackgroundLigand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium.
DescriptionLYVE1 Recombinant Monoclonal Antibody [11C11]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ9Y5Y7
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human LYVE1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesLymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor), LYVE1, CRSBP1 HAR XLKD1
ApplicationELISA, IF, FC; Recommended dilution: IF:1:50-1:200, FC:1:50-1:200