BackgroundCell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
DescriptionMADCAM1 Recombinant Monoclonal Antibody [12B5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ13477
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human MADCAM1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1), MADCAM1
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200