BackgroundStress-activated kinase with diverse functions including cytokine production, cytoskeletal reorganization, DNA damage response, and transcriptional regulation. Activated by MAP kinase p38-alpha/MAPK14 upon stress, it phosphorylates substrates like ALOX5, CDC25B, HSP27/HSPB1, and more. Implicated in inflammatory response by regulating TNF and IL6 production post-transcriptionally. Involved in G2/M checkpoint after DNA damage, late G2/M checkpoint by stabilizing GADD45A mRNA, and toll-like receptor signaling.
DescriptionMAPKAPK2 Recombinant Monoclonal Antibody [4H8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP49137
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human MAPKAP Kinase 2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1), MAPKAPK2
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200