BackgroundPromotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
DescriptionMapt Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityRat
IsotypeIgG
Uniprot IDP19332
Purification>95%, Protein G purified
ImmunogenRecombinant Rat Microtubule-associated protein tau protein (2-752AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesNeurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Mapt, Mtapt, Tau
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000