BackgroundTranscription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
DescriptionNFE2L2 Recombinant Monoclonal Antibody [2D12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ16236
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Nrf2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesNuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2), NFE2L2, NRF2
ApplicationELISA, IF; Recommended dilution: IF:1:20-1:200