BackgroundConstitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
DescriptionNox4 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityRat
IsotypeIgG
Uniprot IDQ924V1
Purification>95%, Protein G purified
ImmunogenRecombinant Rat NADPH oxidase 4 protein (210-424AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesKidney oxidase-1 Kidney superoxide-producing NADPH oxidase Nox4 Kox
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000