This product was discontinued; sorry for the inconvenience. We recommend the following: Cat.# A56386.
BackgroundThis gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
DescriptionNPHS1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityMouse, Rat
IsotypeIgG
Uniprot IDO60500
PurificationAffinity Purification
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1100 to the C-terminus of human NPHS1 (NP_004637.1).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesNPHS1; CNF; NPHN; nephrin
ApplicationWB; Recommended dilution: WB 1:500 - 1:2000