BackgroundComponent of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).
DescriptionNUP153 Recombinant Monoclonal Antibody [8D4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP49790
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Nup153
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesNuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153), NUP153
ApplicationELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200