BackgroundThis gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
DescriptionPhospho-Estrogen Receptor alpha-S167 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman
IsotypeIgG
Uniprot IDP03372
PurificationAffinity Purification
ImmunogenA phospho specific peptide corresponding to residues surrounding S167 of human Estrogen Receptor alpha
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesESR1; ER; ESR; ESRA; ESTRR; Era; NR3A1; estrogen receptor
ApplicationWB, IHC, IF; Recommended dilution: WB: 1:500-1:2000, IHC: 1:50-1:100, IF:1:100-1:200