BackgroundMulti-functional kinase in cell processes like proliferation, differentiation, apoptosis, and transcription. Part of the SAP/JNK pathway, phosphorylating AP-1 components. Regulates replication, apoptosis, autophagy, and neuronal dynamics. Involved in T-cell differentiation and circadian clock. Impacts multiple substrates like p53, BAD, SIRT1, and HSF1.
DescriptionPhospho-MAPK8/MAPK9/MAPK10 (T183/T183/T221) Recombinant Monoclonal Antibody [1A9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP45983/P45984/P53779
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-MAPK8/MAPK9/MAPK10 (T183/T183/T221)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200