BackgroundSerine/threonine kinase that phosphorylates transcription factors like CREB1, ATF1, RELA, STAT3, and ETV1/ER81 in response to mitogenic or stress signals. This contributes to gene activation through histone phosphorylation and regulation of inflammatory genes. It plays a role in controlling RELA activity in response to TNF and glucocorticoid, impacting inflammatory gene expression. Also, phosphorylates histones H2A and H3, and mediates phosphorylation of HMGN1/HMG14 and TRIM7. Involved in neuronal cell death and growth factor signalin
DescriptionPhospho-RPS6KA5 (S376) Recombinant Monoclonal Antibody [2F3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDO75582
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human Phospho-RPS6KA5 (S376)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesRibosomal protein S6 kinase alpha-5, S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL, RPS6KA5, MSK1
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200