BackgroundPhosphoinositide-3-kinase (PI3K) generates PIP3 by phosphorylating PtdIns, PtdIns4P, and PtdIns(4,5)P2. PIP3 recruits PH domain-containing proteins like AKT1 and PDPK1, initiating growth, survival, and motility signaling. Responds to growth factors, activates AKT1 via receptor tyrosine kinases (e.g., EGF, insulin). Supports vascular and lymphatic development, regulates endothelial cell migration through VEGFA signaling. Involved in invadopodia formation, cardiomyogenesis, and vasculogenesis. Has serine-protein kinase activity, phosphorylates PIK3R1, EIF4EBP1, and HRAS. Facilitates phagocytosis and pinocytosis.
DescriptionPIK3CA Recombinant Monoclonal Antibody [10E5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse
IsotypeRabbit IgG
Uniprot IDP42336
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1), PIK3CA
ApplicationELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200