BackgroundA PKC-related kinase involved in cell cycle, cytoskeleton, migration, and transcription. Phosphorylates CTTN, HDAC5, and regulates RhoA targets. Required for cell cycle progression, cell adhesion, and cytokinesis. Stimulates FYN kinase, regulates cell migration, inhibits Akt, and mediates Rho-induced transcription. Involved in ciliogenesis regulation.
DescriptionPKN2 Recombinant Monoclonal Antibody [20A8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ16513
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human PKN2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesSerine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2), PKN2, PRK2 PRKCL2
ApplicationELISA, WB, IHC, IF, FC; Recommended dilution: WB:1:500-1:2000, IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200