BackgroundPlays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e. g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
DescriptionPRF1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDP10820
PurificationProtein G purified
ImmunogenRecombinant Mouse Perforin-1 protein (21-554AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesPerforin-1, P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, PFP
ApplicationELISA, WB, IF; Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200