BackgroundThis serine/threonine-protein kinase functions in T-cell receptor signaling, activating transcription factors like NF-kappa-B, JUN, and NFATC1/2, crucial for T-cell activation, differentiation, and survival. It plays roles in IL2 production and calcium-dependent transactivation. It activates NF-kappa-B and JUN pathways, influencing immune responses. In platelets, it regulates signaling and granule secretion. It also affects insulin signaling and mediates phosphorylation of various targets in response to different stimuli.
DescriptionPRKCQ Recombinant Monoclonal Antibody [1B2]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse
IsotypeRabbit IgG
Uniprot IDQ04759
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human PKC theta
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProtein kinase C theta type (EC 2.7.11.13) (nPKC-theta), PRKCQ, PRKCT
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000