BackgroundSmall GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
DescriptionRAB27A Recombinant Monoclonal Antibody [2E8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP51159
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human RAB27A
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesRas-related protein Rab-27A (Rab-27) (GTP-binding protein Ram), RAB27A, RAB27
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200