BackgroundNegatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
DescriptionRASSF7 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ02833
Purification>95%, Protein G purified
ImmunogenRecombinant Human Ras association domain-containing protein 7 protein (300-368AA)
StorageShipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesRas association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000