BackgroundCoordinates cell signaling from plasma membrane receptors to focal adhesions and actin stress fibers. Vital for cytokinesis, cleavage furrow formation, and keratinocyte adhesion. Activates PKN2 and may activate PLCE1. Triggered by ARHGEF2, it drives GDP-to-GTP exchange. Vital for SPATA13-mediated cell migration control. In the ERBB2 pathway, it stabilizes microtubules at the cortex by regulating APC, CLASP2, and MACF1. Also modulates KCNA2 potassium channel activity upon CHRM1 activation.
DescriptionRHOA Recombinant Monoclonal Antibody [1C11]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP61586
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Rho
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesTransforming protein RhoA (Rho cDNA clone 12) (h12), RHOA, ARH12 ARHA RHO12
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000