BackgroundS100A9 is a calcium- and zinc-binding protein with vital roles in inflammation and immune response. It prompts neutrophil actions like chemotaxis, adhesion, and bactericidal activity. As calprotectin (S100A8/A9), it regulates various functions intracellularly and extracellularly. Inside cells, it aids in leukocyte functions, including arachidonic acid trafficking, cytoskeleton modulation, and NADPH-oxidase activation. Externally, it's proinflammatory, antimicrobial, and antioxidant, interacting with receptors like TLR4 and AGER. It influences apoptosis, neutrophil survival, and inflammation amplification, impacting autoimmunity and cancer. It also functions as a transnitrosylase, mediating S-nitrosylation of various targets in response to oxidative stimuli.
DescriptionS100A9 Recombinant Monoclonal Antibody [2E9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP06702
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human S100A9
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProtein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9), S100A9, CAGB CFAG MRP14
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200