BackgroundInvolved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S. aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.
Descriptionscn Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityStaphylococcus aureus
IsotypeIgG
Uniprot IDQ99SU9
Purification>95%, Protein G purified
ImmunogenRecombinant Staphylococcus aureus Staphylococcal complement inhibitor protein (32-116AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesStaphylococcal complement inhibitor, SCIN, scn, SA1754
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000