BackgroundThis gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in the degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues undergoing remodeling of the extracellular matrix.
DescriptionTIMP2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP16035
PurificationAffinity Purified
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 50-150 of human TIMP2 (NP_003237.2).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesTIMP2; CSC-21K; DDC8; metalloproteinase inhibitor 2
ApplicationWB, IHC, IF: Recommended dilution: WB 1:500 - 1:1000, IHC-P 1:50 - 1:200, IF/ICC 1:50 - 1:200