BackgroundReceptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to Ref. 1, it cannot but according to Ref. 2, it can induce the NF-kappa-B pathway.
DescriptionTNFRSF10D Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ9UBN6
Purification>95%, Protein G purified
ImmunogenRecombinant Human Tumor necrosis factor receptor superfamily member 10D protein (58-208AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesUNQ251/PRO288, DCR2, TRAILR4, TRUNDD, TNFRSF10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD_antigen=CD264
ApplicationELISA, IHC; Recommended dilution: IHC:1:20-1:200