BackgroundNegative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
DescriptionTRAFD1 Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDO14545
Purification>95%, Protein G purified
ImmunogenRecombinant Human TRAF-type zinc finger domain-containing protein 1 protein (2-300AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesTRAF-type zinc finger domain-containing protein 1, Protein FLN29, TRAFD1, FLN29
ApplicationELISA; Recommended dilution: ELISA 1:100-1:500